Entity Address City Or Town
Entity Address, City or Town
Debt Securities, Available-for-Sale, Unrealized Loss Position [Line Items]
Schedule of Reconciliation of U.S. Federal Statutory Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Series B Preferred Stock
Series B Convertible Preferred Stock
Series B Convertible Preferred Stock [Member]
Series B convertible preferred stock.
Entity Ex Transition Period
Entity Ex Transition Period
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Net loss
Fair Value Disclosures [Abstract]
Earnings Per Share [Abstract]
Level 1
Fair Value, Inputs, Level 1 [Member]
Paid-in-Kind Interest
Non-cash interest expense
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Federal
Domestic Tax Authority [Member]
Stock Issued During Period, Value, New Issues
Issuance of common stock in Private Placement, net
Research and Development Costs and Accruals
Research and Development Expense, Policy [Policy Text Block]
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Lease liabilities
Increase Decrease In Lease Liabilities
Increase decrease in lease liabilities.
Right to terminate licensed patents upon prior written notice
Right To Terminate Licensed Patents Upon Prior Written Notice
Right to terminate licensed patents upon prior written notice.
Amendment Flag
Amendment Flag
Right to terminate agreement upon prior written notice if insolvent
Right To Terminate Agreement Upon Prior Written Notice If Insolvent
Right to terminate agreement upon prior written notice if insolvent.
Total value of restricted stock awards, vested based on estimated fair value of stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Accounts receivable
Prepaid Accounts Receivable Current
Prepaid accounts receivable current.
Series B Preferred (as converted to common stock)
Series B Preferred As Converted To Common Stock [Member]
Series B Preferred as converted to common stock member.
Operating loss carryforwards expiration year
Operating Loss Carryforwards Expiration Year
Operating loss carryforwards expiration year.
Total grant date fair value of stock options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Number of authorized shares reserved for issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Subsequent Event Type [Domain]
Research and Development [Abstract]
Agreement termination notice period
Agreement Termination Notice Period
Agreement termination notice period.
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table]
Right of use assets
Operating Lease, Right-of-Use Asset
Hayden LLC
Hayden L L C [Member]
Hayden LLC.
Debt Instrument [Table]
Schedule of Long-Term Debt Instruments [Table]
Less: amount of lease payments representing interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: amount of lease payments representing interest
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Statement [Table]
Statement [Table]
Lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Operating Lease Liability Noncurrent, Total
Noncurrent lease liabilities
Change in accounting principle, accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Annual license fee
Annual License Fee
Annual license fee
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Purchase under Employee Stock Purchase Plan (in shares)
Fair Market Value, Less than 12 Months
Debt Securities, Held-to-Maturity, Continuous Unrealized Loss Position, Less than 12 Months, Fair Value
Preferred stock, outstanding shares
Preferred stock, outstanding shares
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Common stock, shares reserved for issuance
Shares of common stock reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Auditor Firm ID
Auditor Firm Id
Weighted average fair value, Unvested, December 31, 2021
Weighted average fair value, Unvested, December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted average fair value, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Sublease
Sublease
Income Tax Authority
Income Tax Authority [Domain]
Accounting Standards Update 2019-12
Accounting Standards Update 2019-12 [Member]
Product and Service
Product and Service [Axis]
2019 Employee Stock Purchase Plan
Employee Stock [Member]
Series C Preferred (as converted to common stock)
Series C Preferred As Converted To Common Stock [Member]
Series C Preferred As Converted To Common Stock [Member].
Payroll and employee related expenses
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
Lessee, Operating Leases [Text Block]
Leases
Term Loan
Term Loan [Member]
Term loan.
Stock Options Outstanding
Share-Based Payment Arrangement, Option [Member]
Weighted-average remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Total liabilities and stockholders’ equity
Liabilities and Equity
Plan Name
Plan Name [Domain]
Non-Exclusive Patent License Agreement
Non Exclusive Patent License Agreement [Member]
Non-exclusive patent license agreement.
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Change in accounting principle, accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Entity Incorporation State Country Code
Entity Incorporation, State or Country Code
Non-cash lease expense
Non Cash Lease Expenses
Non cash lease expenses.
Lease Expiration Year 1
Lease Expiration Year 1
Lease, expiration year
Subsidiary Or Equity Method Investee Sale Of Stock By Subsidiary Or Equity Investee [Table]
Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table]
Organization
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Proceeds from Stock Plans
Proceeds from Employee Stock Purchase Plan
Sale of Stock
Sale of Stock [Domain]
Number of additional lease extension terms
Operating Lease Number Of Additional Extension Terms
Operating lease number of additional extension terms.
Payment of fee to landlord
Operating Lease Termination Fee
Operating lease termination fee.
Total current liabilities
Liabilities, Current
Issuance of common stock pursuant to restricted stock units (in shares)
Issuance of common stock pursuant to restricted stock units (Shares)
Issuance of common stock pursuant to restricted stock units (Shares)
Stock Issued During Period, Value, Employee Stock Purchase Plan
Purchase under Employee Stock Purchase Plan
Net operating loss carryforwards
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Operating Leases, Future Minimum Payments Due, Next 12 Months
2022
Distribution Type [Axis]
Stock-based compensation expense (in shares)
Shares Issued, Shares, Share-Based Payment Arrangement, before Forfeiture
Recurring Basis
Fair Value, Recurring [Member]
Interest Expense, Total
Interest Expense
Interest expense
Accrued Income Taxes And Other Accrued Liabilities Current
Accrued income taxes and other accrued liabilities, current.
Other
Income Taxes
Income Tax, Policy [Policy Text Block]
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Deferred Tax Assets, Tax Deferred Expense [Abstract]
Unvested Restricted Common Stock
Unvested Restricted Common Stock [Member]
Unvested Restricted Common Stock [Member].
Preferred stock, shares authorized
Preferred stock, authorized shares
Preferred Stock, Shares Authorized
Schedule of Provision
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Variable Rate
Variable Rate [Axis]
Entity Small Business
Entity Small Business
Lease extension term
Operating Leases Additional Extension Term
Operating leases additional extension term.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Investments
Investments [Domain]
Rent and deposits
Prepaid Rent And Deposits Current
Rent and deposits.
Total current assets
Assets, Current
Cumulative change in ownership percentage
Cumulative Change In Ownership Percentage
Cumulative change in ownership percentage.
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Stock Issued During Period, Shares, Restricted Stock Award, Forfeited
Forfeiture of restricted stock (in shares)
City Area Code
City Area Code
Aggregate intrinsic value, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Number of shares, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Share-Based Payment Arrangement [Abstract]
Total liabilities
Liabilities
Private Placement
Private Placement [Member]
Document Period End Date
Document Period End Date
Outstanding stock options.
Outstanding Stock Options [Member]
Outstanding Stock Options
Lease Contractual Term
Lease Contractual Term [Domain]
Restricted Common Stock
Restricted Stock [Member]
Percentage of shares issued from outstanding number of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Construction in Progress
Construction in Progress [Member]
Stock compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Weighted-average grant date fair value of stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Amortization Cost
Debt Securities, Available-for-Sale, Amortized Cost
Software
Software and Software Development Costs [Member]
Statistical Measurement
Statistical Measurement [Axis]
Share Distribution [Member]
Equity Distribution Agreement
Description of future development obligations
Description Of Future Development Obligations
Description of future development obligations.
License agreement entered date
License Agreement Entered Date
License agreement entered date.
Unrealized Loss, Less than 12 Months
Unrealized Loss, Less than 12 Months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Other
Other Assets, Current
Subsequent Event [Line Items]
Restructuring Costs
Restructuring Costs
Restructuring Costs, Total
Preferred stock, voting rights
Preferred Stock, Voting Rights
Total assets
Assets
License agreement extended date
License Agreement Extended Date
License agreement extended date.
Unvested restricted stock units.
Unvested Restricted Stock Units [Member]
Unvested Restricted Stock Units
State
State and Local Jurisdiction [Member]
Operating Leases, Future Minimum Payments, Due in Four Years
2025
Software
Software Development [Member]
Maximum percentage of employee contribution to retirement plan
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Numerator:
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Sale of property and equipment
Sale of property and equipment
Proceeds From (Payment For) Property And Equipment
Proceeds From (Payment For) Property And Equipment
Computation of Diluted Net Loss per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Interest rate floor percentage
Debt Instrument Floor Interest Rate Percentage
Debt instrument floor interest rate percentage.
Upfront fee recognized as revenue
Upfront Fee Recognized As Revenue
Upfront fee recognized as revenue.
Entity Address Postal Zip Code
Entity Address, Postal Zip Code
Amount of funding received as grant
Amount Of Funding Received As Grant
Amount of funding received as grant.
Document Fiscal Period Focus
Document Fiscal Period Focus
Restricted Cash, Total
Restricted Cash
Security deposit classified as restricted cash
Security deposit classified as restricted cash
Short-term marketable securities.
Short Term Marketable Securities [Member]
Short-term Marketable Securities
Total current
Current Income Tax Expense (Benefit)
Operating loss carryforwards, utilization after ownership change
Operating Loss Carryforwards Usage After Ownership Change
Operating Loss Carryforwards Usage After Ownership Change.
Valuation allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance, Total
Preferred stock, $0.001 par value; 10,000,000 shares authorized, no shares issued or outstanding at December 31, 2022 and December 31, 2021, respectively
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Employee Stock Purchase Plan
Employee Stock Purchase Plan Disclosure [Text Block]
Employee stock purchase plan disclosure.
Interest income
Investment Income, Interest
Counterparty Name
Counterparty Name [Domain]
Present value of future lease payments
Lease liability
Operating Lease, Liability
Present value of future lease payments
Net cash (used in) provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Total minimum lease payments
Operating Leases, Future Minimum Payments Due
Statement of Financial Position [Abstract]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Convertible preferred stock, issued shares
Temporary Equity, Shares Issued
Entity File Number
Securities Act File Number
Percentage of eligible employee compensation
Percentage Of Eligible Employee Compensation
Percentage of eligible employee compensation.
Scenario
Scenario [Domain]
Statement of Cash Flows [Abstract]
Long term marketable securities.
Long Term Marketable Securities [Member]
Long-term Marketable Securities
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Sublease income
Sublease Income
Employee Benefit Plan
Retirement Benefits [Text Block]
Furniture and Office Equipment
Furniture And Office Equipment [Member]
Furniture and office equipment.
Geographical
Geographical [Domain]
Statistical Measurement
Statistical Measurement [Domain]
Statement of Stockholders' Equity [Abstract]
Sale of Stock
Sale of Stock [Axis]
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Other comprehensive loss:
Auditor Location
Auditor Location
Class of Stock
Class of Stock [Domain]
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual, Ending Balance
Loss Contingency Accrual
Legal contingencies, accruals recorded
Net loss per share attributable to common stockholders-basic and diluted
EarningPerShareBasicAndDiluted
EarningPerShareBasicAndDiluted
Legal Entity
Legal Entity [Axis]
Schedule of Leases
Lease, Cost [Table Text Block]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Series A Preferred (as converted to common stock)
Series A Preferred As Converted Common Stock [Member]
Series A Preferred as converted to common stock member.
Subsequent Events [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Weighted average remaining contractual term (in years), Options exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Net proceeds from issuance of common stock
Long-term Debt, Type
Long-Term Debt, Type [Axis]
Total Deferred
Deferred Income Tax Expense (Benefit)
Research and development tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Percentage of shares of common stock issued
Percentage Of Shares Of Common Stock Issued
Percentage of shares of common stock issued.
Grant
Grant [Member]
Net operating loss carryforwards without expiration
Net Operating Loss Carryforwards Expiration Without Limitation
Net operating loss carryforwards expiration without limitation.
Concentration of Credit Risk and Off-balance Sheet Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Antidilutive Securities
Antidilutive Securities [Axis]
Debt instrument prepayment premium percentage
Debt Instrument Prepayment Premium Percentage
Debt instrument prepayment premium percentage.
Loan Agreement
Loan And Security Agreement [Member]
Loan and security agreement.
Preferred Stock, value per share
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Property And Equipment
Property And Equipment Table [Text Block]
Property and equipment.
Unrealized Gain
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Funding payments as consideration to support research activities
Funding Payments Made As Consideration To Support Research Activities
Funding payments made as consideration to support research activities.
Subsequent events
Subsequent Events [Text Block]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Finite-Lived Intangible Assets, Major Class Name
Finite-Lived Intangible Assets, Major Class Name [Domain]
Royalty Expense
Royalty payment
Gain (Loss) on Disposition of Assets, Total
Gain (Loss) on Disposition of Assets
Loss on disposal of assets
General and Administrative
General and Administrative Expense [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Convertible preferred Stock, shares issued upon conversion
Convertible Preferred Stock, Shares Issued upon Conversion
Total unrecognized stock-based compensation expense relating to unvested stock options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Current Fiscal Year End Date
Current Fiscal Year End Date
Investment Type
Investment Type [Axis]
MEE
Massachusetts Eye And Ear [Member]
Massachusetts eye and ear.
Depreciation expense
Depreciation expense
Depreciation
Depreciation, Total
2024
Future Minimum Sublease Rentals, Sale Leaseback Transactions, within Two Years
Financial Instruments [Domain]
joint cost
joint cost
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, cash equivalents, and restricted cash at beginning of period
Cash, cash equivalents, and restricted cash at end of period
Permanent differences
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Series B-1 Preferred Stock
Series B-1 Convertible Preferred Stock
Series B1 Convertible Preferred Stock [Member]
Series B-1 convertible preferred stock.
Total stockholders’ equity
Beginning Balance
Ending Balance
Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest
Entity Address Address Line
Entity Address, Address Line One
Total
Pre-tax net loss
Pre-tax net loss
Tax credit carryforwards expiration year
Tax Credit Carryforward Expiration Year
Tax credit carryforward expiration year.
Non-controlling Interest
Noncontrolling Interest [Member]
Royalty Payment and future milestone payments
Payments to Acquire Mineral Rights
Document Annual Report
Document Annual Report
Deferred tax liabilities:
Deferred Tax Liabilities Tax Deferred Expense [Abstract]
Deferred tax liabilities tax deferred expense.
Finite-Lived Intangible Assets by Major Class
Finite-Lived Intangible Assets by Major Class [Axis]
Supplemental Cash Flow Information [Abstract]
Supplemental disclosures:
Subsidiary Sale Of Stock [Line Items]
Subsidiary, Sale of Stock [Line Items]
Lease expiration date
Lease Expiration Date
Other long-term assets
Other long-term assets
Restricted cash
Restricted Cash, Noncurrent
Royalty
Royalty [Member]
Total (benefit) provision
Net tax benefit
Income Tax Expense (Benefit)
Income taxes
Increase in lease liability
Increase (Decrease) in Operating Lease Liability
Share-based compensation arrangement by share-based payment award, award vesting description.
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Description
Vesting description
Income Taxes
Income Tax Disclosure [Text Block]
Preferred stock, issued shares
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Property, Plant, and Equipment, Total
Stock compensation deductions
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Income Tax Disclosure [Abstract]
Percentage of royalty on sublicense revenue.
Percentage of Royalty on Sublicense Revenue
Percentage of royalty on sublicense revenue
Commitment payments related to research
Long-Term Purchase Commitment, Amount
Change in accounting principle, accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Lease Termination Agreement
Leases Termination Agreement [Member]
Lease termination agreement.
Common stock shares issued and sold
Stock Issued During Period, Shares, New Issues
Issuance of common stock in Private Placement, net (in shares)
Right to terminate agreement upon prior written notice
Right To Terminate Agreement Upon Prior Written Notice
Right to terminate agreement upon prior written notice.
Asia
Asia [Member]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Lease agreement amended date
Operating Lease Agreement Amended Date
Operating lease agreement amended date.
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Auditor Name
Auditor Name
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Equity [Abstract]
2023
Future Minimum Sublease Rentals, Sale Leaseback Transactions, Next 12 Months
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Schedule of Future Aggregate Minimum Payments
Revenue recognized potential development milestone payments to receive
Contract with Customer, Liability, Revenue Recognized
Third-party research and development expenses
Accrued Third Party Research And Development Expenses Current
Accrued third-party research and development expenses current.
Weighted average exercise price, Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
State rate changes
Effective Income Tax Rate Reconciliation, Tax Contingency, State and Local, Percent
Loss from operations
Operating Income (Loss)
Shares issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Lessee, Operating Lease, Option to Extend
Lease, description of option to extend
Preferred stock, net proceeds from shares issued
Temporary Equity, Carrying Amount, Attributable to Parent
Cost related to stock options, stock based compensation
Cost related to stock options, stock based compensation
Deferred Compensation Arrangement with Individual, Allocated Share-Based Compensation Expense
Scenario
Scenario [Axis]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Remaining pre ownership change in operating loss carryforwards written off due to expiration
Remaining Pre Ownership Change In Operating Loss Carryforwards Written Off Due To Expiration
Remaining pre ownership change in operating loss carryforwards written off due to expiration.
Professional fees
Accrued Professional Fees, Current
Unrealized Loss
Unrealized Loss
Debt Securities, Available-for-Sale, Unrealized Loss Position
Entity Filer Category
Entity Filer Category
Payments to Acquire Marketable Securities, Total
Payments to Acquire Marketable Securities
Purchase of marketable securities
Proceeds from Sale and Maturity of Marketable Securities, Total
Proceeds from Sale and Maturity of Marketable Securities
Redemption of marketable securities
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total comprehensive loss
Total operating expenses
Operating Expenses
Entity Current Reporting Status
Entity Current Reporting Status
Fair Market Value, More than 12 Months
Debt Securities, Held-to-Maturity, Continuous Unrealized Loss Position, 12 Months or Longer, Fair Value
State
Current State and Local Tax Expense (Benefit)
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Aggregate intrinsic value, Options exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Prime Rate
Prime Rate [Member]
MIT
Massachusetts Institute Of Technology [Member]
Massachusetts Institute of Technology.
Short-term marketable securities
Debt Securities, Available-for-Sale, Current
Debt Securities, Available-for-sale, Current, Total
Stockholders' Equity Note Disclosure [Text Block]
Stockholders' Equity
Lab Equipment
Lab Equipment [Member]
Lab equipment.
Accumulated Other Comprehensive Income
AOCI Attributable to Parent [Member]
Convertible preferred stock, authorized shares
Temporary Equity, Shares Authorized
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Schedule of Financial Assets Measured at Fair Value on Recurring Basis
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement Location
Income Statement Location [Axis]
Number of shares, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of shares, Forfeited
Common stock, $0.001 par value; 200,000,000 shares authorized, 35,262,083 and 34,611,213 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
ARE-MA Region No. 20, LLC
A R E M A Region No20 L L C [Member]
ARE-MA Region No. 20, LLC.
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Lab Equipment
Equipment [Member]
Accumulated Other Comprehensive Income
Equity Components [Axis]
Consolidated Entities
Consolidated Entities [Domain]
Accounting Standards Update
Accounting Standards Update [Domain]
Accounting Standards Update 2016-13
Accounting Standards Update 2016-13 [Member]
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Right to terminate agreement if breach remains uncured
Right To Terminate Agreement If Breach Remains Uncured
Right to terminate agreement if breach remains uncured.
Net operating loss carryforwards expire through 2037
Net Operating Loss Carryforwards Expiration With Limitation
Net operating loss carryforwards expiration with limitation.
Leases [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Operating expenses:
Operating Expenses [Abstract]
Interest Expense, Debt, Total
Interest Expense, Debt
Agreement term
Term Of Agreement
Term of agreement.
Federal
Current Federal Tax Expense (Benefit)
2019 Plan
Two Thousand And Nineteen Incentive Award Plan [Member]
Two thousand and nineteen incentive award plan.
Revenue Recognition
Revenue [Policy Text Block]
Fair value of term loan
Fair Value Of Term Loan
Fair value of term loan.
Schedule Of Stock By Class [Table]
Schedule of Stock by Class [Table]
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Europe
Europe [Member]
Issuance of common stock under equity offering
Stock Issued During Period Shares Under Equity Offering Amount
Stock Issued During Period Shares Under Equity Offering Amount
Entity Voluntary Filers
Entity Voluntary Filers
Federal
Deferred Federal Income Tax Expense (Benefit)
Loans Payable to Bank, Noncurrent
Term Loan, net of current portion
Research and Development
Research Tax Credit Carryforward [Member]
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Income taxes disclosure.
Retirement Benefits [Abstract]
Document Transition Report
Document Transition Report
Operating Leases, Future Minimum Payments, Due Thereafter
2027 and beyond
Schedule of Reconciliation Pre-tax Income
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Weighted average fair value, Awarded
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Lexington Massachusetts facility
Lexington Massachusetts Facility [Member]
Lexington Massachusetts facility.
Accrued Expenses
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Research and Development
Research And Development [Member]
Research and Development.
Impairment losses
Impairment, Long-Lived Asset, Held-for-Use
Impairment, Long-Lived Asset, Held-for-Use, Total
Annual License Fee Per Share
Annual License Fee Per Share
Annual license fee per share
Sale of Stock, Price Per Share
Common stock, sale of price per share
Collaboration Agreement
Collaborative Arrangement Disclosure [Text Block]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Aggregate intrinsic value of stock options exercised
Weighted average exercise price, Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive (loss) income
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
State
Deferred State and Local Income Tax Expense (Benefit)
Fixed assets
Deferred Tax Assets Liabilities Property Plant And Equipment
Deferred tax assets liabilities property plant and equipment.
Other Comprehensive Income (Loss), Net of Tax
Other Comprehensive Income (Loss), Net of Tax, Total
Other comprehensive income loss
Rentable square feetspace
Net Rentable Area
Monthly interest only payments due
Debt Instrument Interest Only Payment Maturity Date
Debt instrument interest only payment maturity date.
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Accounting Standards Update 2018-11
Accounting Standards Update 2018-11 [Member]
Cambridge
Cambridge Enterprise Limited [Member]
Cambridge Enterprise Limited.
Lease liabilities, current portion
Less: current lease liabilities
Current lease liabilities
Operating Lease, Liability, Current
Operating Lease, Liability, Current, Total
SalioGen Therapeutics, Inc. [Member]
SalioGen Therapeutics, Inc.
Capitalized research and development costs
Deferred Tax Assets, in Process Research and Development
Additional-paid in Capital
Additional Paid-in Capital [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Repayment of term loan
Repayment of term loan
Repayment of Long-Term Debt, Long-Term Lease Obligation, and Capital Security
Repayment of Long-Term Debt, Long-Term Lease Obligation, and Capital Security, Total
Operating loss carryforwards, utilization after 15 years thereafter after ownership change
Operating Loss Carryforwards Annual Usage For Next Each After Five Years And Thereafter After Ownership Change
Operating loss carryforwards annual usage for next each after five years and thereafter after ownership change.
Frequency Japan
Subsidiaries [Member]
Entity Registrant Name
Entity Registrant Name
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Summary of Grant-date Fair Value of Stock Options Granted on Weighted Average Basis
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Class of Stock
Class of Stock [Axis]
Loan maturity date
Debt Instrument, Maturity Date
Total future sublease income
Future Minimum Sublease Rentals, Sale Leaseback Transactions
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Statement of Comprehensive Income [Abstract]
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Weighted average remaining contractual term (in years), Options unvested as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-average shares of common stock outstanding-basic and diluted
Weighteds Average Number Of Share Outstanding Basic And Diluted
Weighteds Average Number Of Share Outstanding Basic And Diluted
Award Type
Award Type [Domain]
Statement [Line Items]
Statement [Line Items]
Transaction price allocated to single combined performance obligation
Revenue Recognition Transaction Price
Revenue recognition transaction price.
Lease expense
Operating Lease, Expense
Temporary Equity By Class Of Stock [Table]
Temporary Equity, by Class of Stock [Table]
Weighted average exercise price, Options unvested as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Title of 12(b) Security
Title of 12(b) Security
Accounts payable
Accounts payable
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accounts Payable, Total
Common Stock
Common Stock [Member]
Options expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Equity Component
Equity Component [Domain]
Decrease in research and development expenses
Increase Decrease In Research And Development Expense
Increase (decrease) in research and development expenses.
Schedule of Common Stock Shares Reserved for Future Issuance
Schedule Of Common Stock Shares Reserved For Future Issuance Table [Text Block]
Schedule of common stock shares reserved for future issuance.
Total revenue
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Entity Address State Or Province
Entity Address, State or Province
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Geographical
Geographical [Axis]
Operating loss carryforwards, utilization after five years after ownership change
Operating Loss Carryforwards Annual Usage For Next Each Five Years After Ownership Change
Operating loss carryforwards annual usage for next each five years after ownership change.
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net (decrease) increase in cash, cash equivalents, and restricted cash
Document Type
Document Type
Interest Paid, Excluding Capitalized Interest, Operating Activities
Cash paid for interest
Payments received under collaboration agreement
Proceeds from Collaborators
LLC(FT-FJ)
Delaware Limited Liability Company [Member]
Delaware Limited Liability Company.
Right to terminate agreement incase of nonpayment
Right To Terminate Agreement Incase Of Nonpayment
Right to terminate agreement incase of nonpayment.
Non-controlling Interest
Noncontrolling Interest Disclosure [Text Block]
Prepaid Expenses And Other Current Assets [Text Block]
Prepaid expenses and other current assets.
Prepaid Expenses and Other Current Assets
Entity Shell Company
Entity Shell Company
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Fair Value Measurements
Fair Value of Financial Instruments, Policy [Policy Text Block]
Series A Preferred Stock
Series A Convertible Preferred Stock
Series A Convertible Preferred Stock [Member]
Series A convertible preferred stock.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Grant term period
Grant Term Period
Grant term period.
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Income taxes disclosure.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Lexington Lease
Lexington Lease [Member]
Lexington lease.
Conversion of Frequency Japan Preferred Stock
Conversion Of Frequency Japan Preferred Stock [Member]
Conversion of Frequency Japan preferred stock member.
Security Exchange Name
Security Exchange Name
Payment to director
Payment for Management Fee
Class Of Stock [Line Items]
Class of Stock [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Unrecognized unvested stock options, weighted-average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted average remaining contractual term (in years), Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
2014 Plan
Two Thousand And Fourteen Stock Incentive Plan [Member]
Two thousand and fourteen stock incentive plan.
Commitments and Contingencies Disclosure [Abstract]
Issuance of common stock pursuant to restricted stock units
Issuance Of Common Stock Pursuant To Restricted Stock Units
Issuance Of Common Stock Pursuant To Restricted Stock Units
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of Reconciles the Undiscounted Cash Flows to the Operating Lease Liability
Fair Market Value
Debt Securities, Held-to-Maturity, Unrealized Loss Position, Fair Value
Lease liability
Deferred Tax Assets Leasing Arrangements
Deferred tax assets leasing arrangements.
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Change in deferred tax asset valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Summary of Stock Option Activity under 2014 Plan and 2019 Plan
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Recently Issued And Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
CALIBR
California Institute For Biomedical Research [Member]
California Institute for Biomedical Research.
Common stock, outstanding shares
Beginning Balance (in shares)
Ending Balance (in shares)
Common Stock, Shares, Outstanding
Debt
Debt Disclosure [Text Block]
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Fair Value, Inputs, Level 2 [Member]
Level 2
Fair Market Value
Debt Securities, Available-for-Sale
Debt Securities, Available-for-sale, Total
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Income Tax Authority, Name
Income Tax Authority, Name [Domain]
Common stock, issued shares
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
U.S. Government Treasury Securities
US Treasury Securities [Member]
Variable Rate
Variable Rate [Domain]
Current:
Current Federal, State and Local, Tax Expense (Benefit) [Abstract]
Minimum
Minimum [Member]
Minimum [Member]
Frequency of interest-only payments
Debt Instrument, Frequency of Periodic Payment
Common stock future issuance, description
Share-Based Compensation Arrangement by Share-Based Payment Award, Description
Income Tax Authority, Name
Income Tax Authority, Name [Axis]
Convertible Preferred Stock
Temporary Equity [Text Block]
Temporary equity.
Prepayment Occurs on or Prior to First Anniversary of Closing Date
Prepayment Occurs On Or Prior To First Anniversary Of Closing Date [Member]
Prepayment Occurs on or Prior to First Anniversary of Closing Date.
Deferred:
Deferred Federal, State and Local, Tax Expense (Benefit) [Abstract]
Leases
Lessee, Leases [Policy Text Block]
Weighted average exercise price, Options exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accounting Standards Update
Accounting Standards Update [Axis]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Total
Accrued expenses
Accrued Liabilities, Current
Debt Instrument
Debt Instrument [Axis]
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Foreign currency exchange (losses) gains
Foreign Currency Transaction Gain (Loss), before Tax
Foreign Currency Transaction Gain (Loss), before Tax, Total
Foreign exchange gain (loss)
Issuance of common stock under equity offering (in shares)
Stock Issued During Period Shares Under Equity Offering
Stock Issued During Period Shares Under Equity Offering
Federal and state deferred tax benefits
Deferred Federal, State and Local, Tax Expense (Benefit)
Deferred Federal, State and Local, Tax Expense (Benefit), Total
Counterparty Name
Counterparty Name [Axis]
Entity Address, Address Line Two
Entity Address, Address Line Two
Foreign
Current Foreign Tax Expense (Benefit)
Foreign Currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Royalty Expense Per Share
Royalty Expense Per Share
Royalty expense per share
Weighted average fair value, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Prepayment Occurs After First Anniversary of Closing Date and On or Prior to Second Anniversary of Closing Date
Prepayment Occurs After First Anniversary Of Closing Date And On Or Prior To Second Anniversary Of Closing Date [Member]
Prepayment Occurs After First Anniversary of Closing Date and On or Prior to Second Anniversary of Closing Date.
Lease commencement date
Operating Lease Commencement Date
Operating lease commencement date.
Award Type
Award Type [Axis]
Subsequent Event [Member]
Woburn Massachusetts Facility
Woburn Massachusetts Facility [Member]
Woburn Massachusetts facility.
Series C Convertible Preferred Stock
Series C Convertible Preferred Stock
Series C Convertible Preferred Stock [Member]
Series C convertible preferred stock.
Summary of Significant Accounting Policies
Basis of Presentation and Significant Accounting Policies [Text Block]
Realized Investment Gains (Losses)
Realized Investment Gains (Losses), Total
Realized (loss) gain on investments
Gross deferred tax asset
Deferred Tax Assets, Gross
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate intrinsic value, Exercised
Other income (expense), net
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Long-term Debt, Current Maturities, Total
Long-Term Debt, Current Maturities
Term loan, current portion
Proceeds from Private Placement, net of issuance costs
Proceeds from Issuance of Private Placement
Net proceeds from private placements
Underwater Options reduced
Stock Option, Exercise Price, Decrease
Research and development
Research and Development Expense
Research and Development Expense, Total
Research and development expenses
Prepaid Research And Development Expense Current
Prepaid research and development expense current.
Total minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Operating lease term
Lessee, Operating Lease, Term of Contract
Intangibles
Deferred Tax Assets, Goodwill and Intangible Assets
Entity Central Index Key
Entity Central Index Key
Operating Leases, Future Minimum Payments, Due in Two Years
2023
Accounting Policies [Abstract]
Investments, Debt and Equity Securities [Abstract]
Astellas Pharma LLC
Astellas Pharma Limited Liability Company [Member]
Astellas pharma limited liability company.
Voting percentage of preferred stock holder
Percentage Of Vote Of Holders Of Preferred Stock
Percentage of vote of the holders of preferred stock.
Significant Suppliers
Significant Suppliers Policy [Text Block]
Significant suppliers.
Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Measurement Frequency
Measurement Frequency [Axis]
Common stock, shares available for future grants
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Potential commercial milestone payments eligible to receive upon successful commercialization
Revenue Recognition Potential Commercial Milestone Payments Eligible Upon Successful Commercialization
Revenue recognition potential commercial milestone payments eligible upon successful commercialization.
Stock-based Compensation
Share-Based Payment Arrangement [Text Block]
Right of use asset
Deferred Tax Assets Right Of Use Assets
Deferred tax assets right of use assets.
Insurance
Prepaid Insurance
Subsequent Event [Table]
General and administrative
General and Administrative Expense
General and Administrative Expense, Total
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Weighted average exercise price, Beginning balance
Weighted average exercise price, Ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Losses related to indemnification obligations
Loss Contingency, Loss in Period
Research and Development
Research and Development Expense [Member]
Scenario Forecast
Forecast [Member]
Percentage of employee annual compensation matched by the employer
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
License and Collaboration Agreement
License And Collaboration Agreement [Member]
License and collaboration agreement.
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Accumulated Deficit
Retained Earnings [Member]
Tax Credit Carryforward, Name
Tax Credit Carryforward, Name [Domain]
Money Market Funds
Money Market Funds [Member]
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
License fee payment
License Fee Payment
License fee payment.
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Total
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Additional paid-in capital
Additional Paid in Capital
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Sublease rent per month
Operating Leases, Rent Expense, Sublease Rentals
Entity Interactive Data Current
Entity Interactive Data Current
Tax credit carryforwards
Tax Credit Carryforward, Amount
Entity Public Float
Entity Public Float
Prepayment Occurs After Second Anniversary of Closing Date
Prepayment Occurs After Second Anniversary Of Closing Date [Member]
Prepayment Occurs After Second Anniversary of Closing Date.
Number of shares, Options unvested as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Related Party Transactions [Abstract]
Period of cumulative change in ownership
Period Of Cumulative Change In Ownership
Period of cumulative change in ownership.
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Leasehold Improvements
Leasehold Improvements [Member]
Accounting Standards Update 2018-15 [Member]
Accounting Standards Update 2018-15
Unrealized Loss, More than 12 Months
Unrealized Loss, More than 12 Months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Local Phone Number
Local Phone Number
U.S federal statutory income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Accounting Standards Update 2016-01
Accounting Standards Update 2016-01 [Member]
Unrecognized tax benefits
Unrecognized Tax Benefits
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Description of conditions to terminate license agreement
Description Of Conditions To Terminate License Agreement
Description of conditions to terminate license agreement.
Schedule of Basic and Diluted Net Loss per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Options vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Debt Disclosure [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Phase 2b Clinical Trial
Phase2b Clinical Trial [Member]
Phase 2b clinical trial.
Lease Contractual Term
Lease Contractual Term [Axis]
Number of shares, Options exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
IPO
IPO [Member]
Consolidated Entities
Consolidated Entities [Axis]
Number of shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Other long-term liabilities
Other Liabilities, Noncurrent
Other Liabilities, Noncurrent, Total
Payment terms, description
Debt Instrument, Payment Terms
Income Statement Location
Income Statement Location [Domain]
Property, Plant and Equipment [Abstract]
Number of shares, Unvested, December 31, 2022
Number of shares, Unvested, December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid expenses and other assets
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Date of incorporation
Entity Incorporation, Date of Incorporation
Number of shares, Beginning balance
Number of shares, Ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Two Thousand Fourteen And Two Thousand Nineteen Stock Incentive Plan [Member]
Two Thousand Fourteen And Two Thousand Nineteen Stock Incentive Plan [Member]
2014 and 2019 Plan
Distribution Type [Domain]
Debt Instrument, Name
Debt Instrument, Name [Domain]
Document Fiscal Year Focus
Document Fiscal Year Focus
Prepaid Expense and Other Assets, Current [Abstract]
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Assets
Assets [Abstract]
Accrued expenses
Increase (Decrease) in Accrued Liabilities
Increase (Decrease) in Accrued Liabilities, Total
Net deferred tax asset (liability)
Deferred Tax Assets, Net
Total
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Principal balance
Debt Instrument, Face Amount
Shares Available for Future Grant Under Stock Option Plan
Share-Based Payment Arrangement [Member]
Financial Instrument [Axis]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Deferred revenue
Deferred Tax Assets, Deferred Income
Summary Of Expected Future Sublease Income
Summary Of Expected Future Sublease Income
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
Series A-1 Preferred Stock
Series A-1 Convertible Preferred Stock
Series A1 Convertible Preferred Stock [Member]
Series A-1 convertible preferred stock.
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Income Tax Authority
Income Tax Authority [Axis]
Net deferred tax assets
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Temporary Equity Disclosure [Abstract]
Revenue recognized commercialization milestone payments to receive
Contract With Customer Liability Revenue Recognized From Commercialization Milestones
Contract with customer liability revenue recognized from commercialization milestones.
Current assets:
Assets, Current [Abstract]
Massachusetts
MASSACHUSETTS
Noncontrolling Interest [Abstract]
Debt Securities, Available-for-Sale, Noncurrent
Long-term marketable securities
Schedule of Deferred Tax Assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Schedule of debt securities in an unrealized loss position
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block]
Employers matching contribution
Defined Contribution Plan, Employer Discretionary Contribution Amount
Payables and Accruals [Abstract]
Measurement Frequency
Measurement Frequency [Domain]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Share based compensation arrangement by share based payment award options granted weighted average remaining contractualterm2.
Share Based Compensation Arrangement By Share Based Payment Award Options Granted Weighted Average Remaining Contractual Term2
Weighted average remaining contractual term (in years), Granted
Lease, expiration year
Lease Expiration Year
Lease expiration year.
Scripps Option Agreement
Scripps Option Agreement [Member]
Scripps option agreement.
Operating Leases, Future Minimum Payments, Due in Three Years
2024
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Phase 3 Clinical Trial
Phase3 Clinical Trail [Member]
Phase 3 clinical trail.
Entity
Entity [Domain]
Employers matching contribution vesting percentage
Defined Contribution Plan, Employers Matching Contribution, Annual Vesting Percentage
Domestic
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Cover [Abstract]
Interest and penalties
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Product and Service
Product and Service [Domain]
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Number of shares, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Current liabilities:
Liabilities, Current [Abstract]
Maximum
Maximum [Member]
Percentage of employer matching contribution
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized loss on marketable securities
Patent Costs
Patent Costs Policy [Text Block]
Patent costs.
Net Cash Provided by (Used in) Investing Activities
Net cash (used in) provided by investing activities
Furniture and Office Equipment
Furniture and Fixtures [Member]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Number of shares, Exercised
Options exercised
Issuance of common stock upon exercise of options (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Research and License Agreements
Research And License Agreements Disclosure [Text Block]
Research and license agreements disclosure text block.
Period for automatic increase in common available for future issuance
Period for automatic increase in common stock available for future issuance
Period For Automatic Increase In Common Stock Available For Future Issuance
Period for automatic increase in common stock available for future issuance.
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Debt instrument, Interest rate
Debt Instrument, Basis Spread on Variable Rate
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Segment Information
Segment Reporting, Policy [Policy Text Block]
Increase in right-of-use asset
Increase Decrease In Operating Lease Right Of Use Assets
Increase (decrease) in operating lease right of use assets.
Aggregate intrinsic value, Options unvested as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Property and equipment, estimated useful lives
Property, Plant and Equipment, Useful Life
Sales agent commission
Sales Agent Commission
Sales Agent commission
Additional funding payments made as consideration to support research activities
Additional Funding Payments Made As Consideration To Support Research Activities
Additional funding payments made as consideration to support research activities.
Common stock, authorized shares
Common Stock, Shares Authorized
Trading Symbol
Trading Symbol
Title of Individual
Title of Individual [Domain]
Subsequent Event Type [Axis]
Other
Deferred Tax Assets, Other
Other items
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent, Total
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Patent License Agreement
Patent License Agreement [Member]
Patent license agreement.
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Accounts payable
Accounts Payable, Current
Accounts Payable, Current, Total
Unrealized Loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Plan Name
Plan Name [Axis]
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Title of Individual
Title of Individual [Axis]
Internal Revenue Service
Internal Revenue Service (IRS) [Member]
Debt instrument final payment
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid
Dr. Langer
Director [Member]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Collaborative Arrangements
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Milestone payments
Milestone Payments
Milestone payments.
Common stock, par value
Common Stock, Par or Stated Value Per Share
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Summary of Status of Restricted Common Stock
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Comprehensive Income, Policy [Policy Text Block]
Comprehensive loss
Number of shares, Awarded
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Outstanding Stock Options (as converted to common stock)
Outstanding Stock Options As Converted To Common Stock [Member]
Outstanding stock options as converted to common stock member.
Property and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Leasehold improvements, estimated useful life
Property, Plant and Equipment, Estimated Useful Lives
Weighted average exercise price, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Operating Leases, Future Minimum Payments, Due in Five Years
2026
Fair value of term loan issued term
Fair Value Of Term Loan Issued Term
Fair value of term loan issued term.
Preferred stock, shares purchased
Preferred Stock Shares Purchased
Preferred stock, shares purchased.
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Long-term Debt, Type
Long-Term Debt, Type [Domain]
Antidilutive securities excluded from computation of earnings per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Summary of Prepaid Expenses and Other Current Assets
Summary Of Prepaid Expenses And Other Current Assets Table [Text Block]
Summary of prepaid expenses and other current assets.
Expenses of Stock Based Compensation to be Recognized over vesting period of options
Expenses of stock based compensation to be recognized over vesting period of options
Expenses of stock based compensation to be recognized over vesting period of options